Episodi stagione 5
Meredith e Derek si rendono conto che il loro "lieto fine" non è poi così semplice da portare avanti, mentre Cristina ha una cotta per un medico militare. Intanto il Capo ed il suo staff fronteggiano la notizia che il Seattle Grace non è più considerato tra le migliori cliniche universitarie.
Mentre Meredith e Derek continuano la loro nuova relazione, Cristina approfondisce la sua conoscenza con il medico militare.
La rottura dell'impianto idraulico provoca il panico al Seattle Grace, proprio mentre il capo cercava di mettere in pratica un nuovo metodo d'insegnamento.
Intanto George svolge il suo esame per la residenza, mentre Derek tenta di far andare via i compagni di stanza di Meredith.Meredith entra nel panico quando Derek trova il diario di sua madre in casa. Callie è agitato per il suo primo appuntamento con Erica.
Mentre Cristina si imbatte in una parte dell'ospedale che nessuno aveva mai visto prima.Per risollevare il prestigio dell'ospedale viene proposta una rischiosa "chirurgia a domino". Intanto si crea tensione tra Meredith e Derek, perchè quest'ultimo si è preso tutti i meriti sul loro studio riguardante i tumori al cervello. Sloan consiglia una disperata Callie su faccende amorose...
Il capo dà a Bailey nuovi incarichi e responsabilità. Ma non solo, le assegna il compito di operare una ragazza con un caso disperato di tumore.
Derek chiede consiglio a Bailey perché Cristina continua ad interferire nella sua relazione con Meredith. Erica scopre una scioccante connessione tra un membro interno ed un paziente.
One of Meredith's oldest friends, Sadie, becomes an intern at Seattle Grace, but Mer's friends are less-than-welcoming to her.
Meredith, Cristina and Bailey come to Lexie and Sadie's rescue when a routine surgery goes horribly wrong, as Owen and Derek treat a man seriously injured while sleepwalking and Mark comforts the sleepwalker's distraught daughter.
Cristina is awarded the first solo surgery among the residents, but she is forced to give it up and choose her replacement; Lexie is impressed when Mark performs a cutting-edge procedure; Callie doesn't know if Sadie is friendly or flirtatious.
Bailey teams with Seattle Grace's new pediatric surgeon, Dr. Arizona Robbins, to save the life of a young patient near and dear to her heart, as the admittance of a death row inmate at the hospital stirs anger in Derek and further erodes Meredith and Cristina's friendship; meanwhile, Callie and Sloan work as a team to fight their respective attract...
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Derek's mother, Carolyn, makes a surprise visit to Seattle and meets Meredith for the first time, as Mark tries to conceal his relationship with Lexie from her as well; meanwhile, death row inmate William wishes to donate his organs to Bailey and Arizona's patient, as Owen and Cristina try to go on their first date.
Bailey grows desperate as a patient's condition becomes more and more dire. Everyone in the hospital is stepping up to try to find the boy a new organ donor, including Meredith, who considers a death row patient's wish to die before execution. Meanwhile, an injury leaves Mark in a compromising position in the OR and Cristina awkwardly avoids Owen.
Now that Derek has the engagement ring, he searches for the perfect way to propose to Meredith, as Lexie demands that Mark go public with their relationship, and Bailey, encouraged by her work on recent cases and by Dr. Dixon, considers a new direction for her medical career.
Addison, Naomi and Sam rush the ailing Archer to Seattle Grace and reunite with old friends Derek and Mark to help save his life; meanwhile, Izzie employs her fellow doctors in a medical game designed to help teach the interns, and Owen runs into a significant someone from his past
Derek's confidence is shaken like never before as he faces off with Addison over what course is best for their dying pregnant patient; Cristina calls the abilities of a renown surgeon into question after she botches a standard procedure; and Bailey, who has decided to pursue a fellowship in Pediatrics, is appalled by the Chief's less-than-stellar r...
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Derek decides to quit after learning that more of his patients have died than survived; Izzie's interns make an unsettling discovery about "Patient X."
After his fellow surgeons try and fail to bring Derek back to work, Meredith must summon the strength to convince him. Meanwhile the hospital is abuzz as Mark attempts a rare face transplant surgery. Cristina, at last awarded her first solo surgery, is more focused on the needs of her friends, and Izzie does her best to keep her medical condition a...
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All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.
As she endures aggressive treatment for her cancer, Izzie throws herself into planning Derek and Meredith's wedding.
As preparations continue for Meredith and Derek's wedding, Izzie receives a surprise hospital visit from her handful-of-a-mother, Robbie. Meanwhile, a newly sober Thatcher visits his daughters, Meredith and Lexie, in order to make amends, and the Chief and Meredith bitterly fight over a controversial medical case.
As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms.
In the first part of the two hour season finale, Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark is ready to take his relationship with Lexie to the next level and a patient makes Owen reassess his place at Seattle Grace.
In the second part of the two hour season finale, George delivers stunning news to Bailey, sending shockwaves throughout the hospital, and Izzie's friends anxiously await her recovery from surgery. Meanwhile Bailey is surprisingly displeased after being accepted into the pediatric fellowship program, and the victim of a near-fatal traffic accident ...
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